Ask your health care provider any questions you may have about how to use indinavir. If you miss a dose or forget to use your medicine less than 2 hours, use it as soon as you can. If your next regular dose is more than 2 hours, wait until then to use the medicine and skip the missed dose. Lumefantrine: CYP3A4 Inhibitors Strong may increase the serum concentration of Lumefantrine.
Caucasian subjects consisting of six racial groups. Using indinavir with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Midazolam: Protease Inhibitors may increase the serum concentration of Midazolam. Management: Oral midazolam contraindicated with all protease inhibitors. IV midazolam contraindicated with fosamprenavir and nelfinavir; other protease inhibitors recommend caution, close monitoring, and consideration of lower IV midazolam doses with concurrent use.
Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with Crixivan.
Gagnon RF, Alli AI, Watters AK, Tsoukas CM "Indinavir crystalluria. Rietsema WJ. Fever, erythroderma, abdominal pain, and renal failure following initiation of indinavir therapy. Clin Inf Dis. Elderly: Use with caution in elderly patients. Who should not take Crixivan? Indinavir should always be used in combination with other antiretroviral agents. Indinavir should generally not be added as a single agent when antiretroviral regimens are changed due to the development of drug resistance and loss of virological response.
Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission, US Department of Health and Human Services HHS. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States March 28, 2014. Updates may be available at HHS AIDS Information AIDSinfo website. Dose reduction of Crixivan to 600 mg every 8 hours should be considered when administering delavirdine 400 mg three times a day. Gagnon AM, Angel JB, Sorisky A. Protease inhibitors and adipocyte differentiation in cell culture. Lancet. New onset diabetes mellitus, exacerbation of preexisting diabetes mellitus, hyperglycemia, and in some cases, diabetic ketoacidosis have been reported in HIV-infected patients receiving protease inhibitors. However, no causal relationship has been established. Patients may require initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. Hyperglycemia persisted in some cases after discontinuation of protease inhibitor therapy. ARIPiprazole Lauroxil: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of ARIPiprazole Lauroxil. Management: Please refer to the full interaction monograph for details concerning the recommended dose adjustments. ALERT: Find out about medicines that should NOT be taken with Crixivan. A Patient Package Insert PPI for Crixivan is available for patient information. What are the possible side effects of Crixivan?
Only take medicine that your doctor has prescribed specially for you. Do not share your medicine with others. Prophylaxis should be initiated immediately, preferably within hours after exposure. What other drugs will affect indinavir? Midostaurin: CYP3A4 Inhibitors Strong may increase the serum concentration of Midostaurin. Management: Seek alternatives to the concomitant use of midostaurin and strong CYP3A4 inhibitors if possible. If concomitant use cannot be avoided, monitor patients for increased risk of adverse reactions. Taking Crixivan with the above medications could result in serious or life-threatening problems such as irregular heartbeat or excessive sleepiness. Experts state indinavir without low-dose ritonavir not recommended at any time in pregnant women. 202 Substantially decreased plasma indinavir concentrations reported during pregnancy. 1 202 See Absorption: Special Populations under Pharmacokinetics. ONGLYZA and initiate appropriate management. Fluticasone use is not recommended in situations where CRIXIVAN is coadministered with a potent CYP3A4 inhibitor such as ritonavir unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects. ARIPiprazole: CYP3A4 Inhibitors Strong may increase the serum concentration of ARIPiprazole. Management: See full interaction monograph for details. Ruxolitinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ruxolitinib. Management: This combination should be avoided under some circumstances. See monograph for details. Instruct HIV-infected women not to breast-feed because of risk of HIV transmission and risk of adverse effects in the infant. Indinavir MK 639 pharmacokinetic study group. Indinavir MK 639 drug interactions studies. Carr A, Samaras K, Chisholm DJ et al. Abnormal fat distribution and use of protease inhibitors. Lancet. When used without low-dose ritonavir in pregnant women, only minimal amounts of indinavir crossed the placenta. Alosetron is used to treat severe, chronic irritable bowel syndrome IBS in women who have had diarrhea as the main symptom for at least 6 months. Alosetron should be used only in women who have tried other IBS treatments without success. Alosetron has not been shown to be effective in men with IBS. serevent
Hormonal birth control eg, birth control pills may not work as well while you are using indinavir. To prevent pregnancy, use an extra form of birth control eg, condoms. This may not be a complete list of all interactions that may occur. Fantoni M, Del Borgo C, Autore C "Evaluation and management of metabolic and coagulative disorders in HIV-infected patients receiving highly active antiretroviral therapy. Vindesine: CYP3A4 Inhibitors Strong may increase the serum concentration of Vindesine. Gerberding J. Is antiretroviral treatment after percutaneous HIV exposure justified? Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Many other prescription and nonprescription medicines eg, used for aches or pain, allergies, asthma or other lung or breathing problems, blood thinning, blood vessel problems, cancer, Cushing syndrome, cystic fibrosis, depression or other mental or mood problems, diabetes, erectile dysfunction, gout, high blood pressure, high cholesterol, HIV infection, immune suppression, infections, inflammation, insomnia, irregular heartbeat or other heart problems, migraine headaches, narcotic addiction, nausea or vomiting, overactive bladder, PAH, seizures, stomach or bowel problems multivitamin products, and herbal or dietary supplements eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort may interact with indinavir. Indinavir will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. Indinavir will not keep you from spreading HIV to other people. People who receive indinavir may continue to have other problems usually related to AIDS or HIV disease. Loss of therapeutic effect of Crixivan and possible development of resistance. Optimal dosage not established. 1 See Pediatric Use under Cautions. Anon. HIV seroconversion after occupational exposure despite early prophylactic zidovudine therapy. Lancet. If taking with ritonavir, may take with food. Patient should drink at least 48 oz of water daily. Ocular side effects have included blurred vision, eye pain, eye swelling, and orbital edema. Tacrolimus Systemic: Protease Inhibitors may decrease the metabolism of Tacrolimus Systemic. Trabectedin: CYP3A4 Inhibitors Strong may increase the serum concentration of Trabectedin. unhas.info glucophage
Boruchoff SE, Sturgill MG, Grasing KW et al. The steady-state disposition of indinavir is not altered by the concomitant administration of clarithromycin. Clin Pharmacol Ther. CRIXIVAN. There is increased potential for sildenafil-associated adverse events which include visual disturbances, hypotension, prolonged erection, and syncope. TMP-SMX discontinued therapy due to an adverse reaction. Shaughnessy MV. Emerging international consensus for use of antiretroviral therapy. Lancet. Close monitoring and frequent urinalyses are recommended for patients with asymptomatic severe leukocyturia. Further diagnostic evaluation may be warranted, and discontinuation of indinavir should be considered in all patients with severe leukocyturia. Marijuana might slow blood clotting. Taking marijuana extracts along with medications that also slow clotting might increase the chances of bruising and bleeding. Some MEDICINES MAY INTERACT with indinavir. L of water a day unless otherwise directed by your doctor. These effects may be worse if you take it with alcohol or certain medicines. How often did hospital staff describe possible side effects in a way you could understand? Trough or minimum plasma concentration. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase. AUC and C max slightly increased and trough concentrations were considerably lower.
Ribociclib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ribociclib. Management: Avoid use of ribociclib with strong CYP3A4 inhibitors when possible; if combined use cannot be avoided, reduce ribociclib dose to 400 mg once daily. Blonanserin: CYP3A4 Inhibitors Strong may increase the serum concentration of Blonanserin. IC 95. In general, higher levels of resistance were associated with the co-expression of greater numbers of substitutions, although their individual effects varied and were not additive. At least 3 amino acid substitutions must be present for phenotypic resistance to indinavir to reach measurable levels. Using dexamethasone together with indinavir may alter the effects of both medications. Contact your doctor if you experience thinning skin, easy bruising, changes in the shape or location of body fat especially in your face, neck, back, and waist increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. In addition, combining these medications can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. F. Protect from moisture. cheap telfast mexico
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Tell your doctor if your condition persists or worsens. DPP4 enzyme within minutes. Flibanserin: CYP3A4 Inhibitors Strong may increase the serum concentration of Flibanserin. Tadalafil dose should not exceed a maximum of 10 mg in a 72-hour period in patients receiving concomitant Crixivan therapy. Use with increased monitoring for adverse events. Some medications changed by the liver include acetaminophen, chlorzoxazone ethanol, theophylline, and anesthetics such as enflurane halothane isoflurane methoxyflurane Penthrane. ZERIT is used alone. Severe. These medicines may interact and cause very harmful effects and are usually not taken together. VinCRIStine Liposomal: CYP3A4 Inhibitors Strong may increase the serum concentration of VinCRIStine Liposomal. Tashima KT, Horowitz JD, Rosen S "Indinavir nephropathy. This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day. Stop taking alosetron if your IBS symptoms do not improve after 4 weeks of treatment. If you stop taking alosetron, do not start taking it again without your doctor's advice. Both atazanavir and indinavir can increase the amount of bilirubin in your blood. For males, in the very unlikely event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and seek immediate medical attention, or permanent problems could occur. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. What is alosetron Lotronex? indian tegretol
AUC, C max or trough concentration. Levitra, Staxyn or by international labeling. See full drug interaction monograph for details. Do not split or cut ONGLYZA tablets. Ergot Derivatives: Protease Inhibitors may increase the serum concentration of Ergot Derivatives. Exceptions: Nicergoline. Can Crixivan be taken with other medications? Indinavir deposition in synovial fluid may have resulted in monoarthritis in a patient. It belongs to a class of called which act on the and nerves to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body GABA. Gerberding JL. Management of occupational exposures to blood-borne viruses. N Engl J Med.
Dose titration of ONGLYZA was not permitted during the study. DPP4 inhibitor, which is one-half as potent as saxagliptin. The pharmacokinetic profiles of indinavir in pediatric patients were not comparable to profiles previously observed in HIV-infected adults receiving the recommended dose of 800 mg every 8 hours. The AUC and C max values were slightly higher and the trough concentrations were considerably lower in pediatric patients. Approximately 50% of the pediatric patients had trough values below 100 nM; whereas, approximately 10% of adult patients had trough levels below 100 nM. The relationship between specific trough values and inhibition of HIV replication has not been established. Importance of advising patients of other important precautionary information. 1 See Cautions. The solution may appear slightly hazy. Ramelteon: CYP3A4 Inhibitors Strong may increase the serum concentration of Ramelteon. Laboratories, Inc. September, 2016. Concomitant use of fluticasone propionate and CRIXIVAN may increase plasma concentrations of fluticasone propionate. Use with caution. Consider alternatives to fluticasone propionate, particularly for long-term use. ONGLYZA should be administered following hemodialysis. Hepatitis, hepatic failure, hepatic cytolysis, pancreatitis including at least one case with lactic acidosis jaundice, liver function abnormalities, increased serum triglycerides, and cirrhosis have been reported during postmarketing experience. Lovastatin: CYP3A4 Inhibitors Strong may increase the serum concentration of Lovastatin. Nuesch R, Srasuebkul P, Ananworanich J, Ruxrungtham K, Phanuphak P, Duncombe C "Monitoring the toxicity of antiretroviral therapy in resource limited settings: a prospective clinical trial cohort in Thailand. Crixivan is not a cure for HIV-1 infection and patients may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections. Patients should remain under the care of a physician when using Crixivan. TraZODone: Indinavir may increase the serum concentration of TraZODone. Management: Consider using a lower dose of trazodone when used in combination with indinavir. What is the most important information I should know about alosetron Lotronex? buy cefdinir wiki
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PredniSONE: CYP3A4 Inhibitors Strong may increase the serum concentration of PredniSONE. Bosentan: Indinavir may increase the serum concentration of Bosentan. Bosentan may decrease the serum concentration of Indinavir. Take this medication by as directed by your doctor, usually once daily in the morning. not take with a high- meal because doing so can increase the risk of side effects. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Dosage is based on your medical condition, age, and response to treatment. Your dose may be gradually increased until the drug starts working well. Follow your doctor's instructions closely to reduce the risk of side effects. cost of valtrex prescription
Read the Guide provided by your before you start using and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Concomitant use of fluticasone propionate and Crixivan may increase plasma concentrations of fluticasone propionate. Use with caution. Consider alternatives to fluticasone propionate, particularly for long-term use. When taken together, St. John's wort may cause your body to process your HIV medication more quickly. Haas DW, Stone J, Clough LA et al. Steady-state pharmacokinetics of indinavir in cerebrospinal fluid and plasma among adults with human immunodeficiency virus type 1 infection. Clin Pharmacol Ther.
There have been more than 60 reports of acute or chronic human overdosage up to 23 times the recommended total daily dose of 2400 mg with Crixivan. Efavirenz: May decrease the serum concentration of Indinavir. Management: The appropriate dose adjustments for indinavir when used together with efavirenz are unknown. The use of higher unboosted indinavir doses is not likely an adequate approach. Use of a ritonavir-boosted indinavir regimen could be considered. Lui A, Karter D, Turett G "Another case of breast hypertrophy in a patient treated with indinavir. Educate patient about signs of a significant reaction eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. biaxin
Do not take alosetron if you are also taking fluvoxamine Luvox to treat obsessive-compulsive disorder. Nefazodone: Protease Inhibitors may increase the serum concentration of Nefazodone. Management: Consider alternatives to, or reduced doses of, nefazodone in patients treated with HIV protease inhibitors. Monitor patients receiving these combinations closely for toxic effects of nefazodone. If you take Crixivan with RESCRIPTOR, your doctor may adjust the dose of Crixivan. Soriano V, Puoti M, Sulkowski M, et al. "Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV International Panel.